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Moreover, this trial found that disulfide linker lability and rapid deconjugation in MLN2704 led to significant neurotoxicity, with 44 (71%) patients experiencing dose-limiting peripheral neuropathy halting clinical development 71
The researchers also noted that areas of the brain with higher glutathione concentrations are more resilient to the aging process, explaining the better memory and learning outcomes
The exception to that is found, however, in many disease states (including hyper- and hypo-thyroid states), as well as in conditions relating to specific types of diets (high-fat, high-protein, and low-carb)
Nature 398 , 630634 (1999)
KLOW thus additionally covers inflammation modulation
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