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Disfuno das clulas beta: necessidade de insulina a longo prazo secreo de insulina defeituosa Resulta em hiperglicemia A abordagem farmacolgica pode ter como alvo a: Libertao de insulina Resistncia insulina Libertao de glucagon Glucagon A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal glucagon-like peptides

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