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J Basic Med Sci (2020) 23:11249

Notably, breast cancer cells exhibit elevated aerobic respiration due to their highly active mitochondrial metabolism, which may potentiate tumour angiogenesis via the cuproptosis pathway, thereby fostering a tumour-promoting microenvironment [95]

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Within the cyst(e)ine/GSH/GPX4 axis, cysteine is the rate-limiting metabolite for GSH biosynthesis, hence the ferroptosis-inducing activity of cyst(e)ine depletion has largely been attributed to the lowering of intracellular GSH levels and subsequent decrease of GPX4 activity

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