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The main difference between Tirzepatide and Semaglutide is that Tirzepatide works on the GIP AND GLP-1 receptors , while Semaglutide works on the GLP-1 receptors

Clin Perinatol 25: 963, 1998 29 Malone FD, Canick JA, Ball RH et al: First-trimester or second-trimester screening, or both, for Down's syndrome