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Mechanism of action: melanocortin cAMP/PKA/MITF cascade Presynaptic activation of cutaneous MC1R and central MC3R/MC4R/MC5R PRIMARY PATHWAY MELANOGENESIS MC1R on melanocytes High-affinity binding to the MC1R receptor on epidermal melanocytes

Khan, R

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This study was supported in part by Science and Technology Department of Zhejiang Province (2023C03046)

The study points to several anti-inflammatory effects that matter in MCAS: * Reduced activation of inflammatory pathways like TNF- and NF-B * Suppression of the NLRP3 inflammasome (a key driver of chronic inflammation) * Calming of mast-cell-driven immune overactivity In simpler terms: these medications may help mast cells chill out

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