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These are approximate ranges from research literature
Among patients with type 2 diabetes, GLP-1 use was associated with a 32% lower risk of fracture for those with osteopenia and for those with osteoporosis, as seen in Figure 1
doi: 10.1097/MED.0b013e32835edb32 232 KawaiTSunBYoshinoHFengDSuzukiYFukazawaMet al
Since it mimics a peptide already produced by the body, it's generally considered safe for short- or long-term use
The FDA prescribing information for semaglutide and tirzepatide also carries a thyroid C-cell tumor warning from animal studies - the human relevance hasn't been established, but it's why patients with a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome aren't candidates
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