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The compound exhibits a notably long half-life of approximately 9 days (220 hours) and is metabolized primarily by cytochrome P450 3A4 to its active metabolite M1 (NS2360), which has an even longer half-life of 16 days (374 hours)

However, tenodesis may be needed when the biceps tendon is severely degenerated or when shoulder reconstruction for other problems is needed

Availability, vial sizes, batch records, and ordering requirements can be reviewed on the Cernum Biosciences website

do not use if cloudy or particulate present

In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision

Always keep the vials protected from light