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The glutathione S-transferase (GST)-protein is frequently used to tag a protein of interest because of its affinity for the reduced form of the tripeptide, glutathione [6]
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However, PGE2 is known to play a dual role, as it can both suppress the immune response against M.tb and protect the host from excessive inflammation, suggesting that NSAIDs should be exercised with caution for TB treatment [128]
In human studies, translation remains limited, as clinical trials are generally small, short-term and heterogeneous in design, dosing and endpoints, with some reporting no significant effects
The benefit profile is real, but the magnitude is typically modest compared to modern combination therapies
The supplement industry varies in quality
