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They are all closely dependant on each other so the absence of one will critically effect the activity of all others

The narrowing can occur anywhere along the spine, but most often happens in the low back

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10.1016/j.devcel.2015.01.010 Dev

In contrast, the MGST, TCHQD, GHR, DHAR, and GST2N classes contained fewer members, possibly due to the scattering of these classes on different chromosomes, prohibiting tandem duplication (Supplementary Figure S2)