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Although food is the best medicine, supplementation supports the lifestyle changes and fills in any genetic weakness
244,245 DJ-1 also binds to the DNA-binding domain of p53, diminishing the DNA-binding affinity of p53 and inhibiting the expression of p53 target genes in a manner that relies on the oxidation of cysteine 106
Several studies collectively support the hypothesis that redox dysregulation is central to ALS pathogenesis, particularly in genetically predisposed individuals
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C., Gallez, B., and Jordan, B
