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GLP-2 does not increase the protein expression of FATP4 or MTP, rather it significantly increases the expression of glycosylated CD36
Importantly, the inhibition of BTK and SYK pathways, implicated in the amplification NF-B and MAPK-mediated inflammatory cascades and intersecting with the JAK/STAT network [246, 250], could support a translational link between B-cell-driven inflammation and attenuation of fibrosis in HS lesions
Indirect mechanisms relate to weight loss, improved glycaemic control, and reduced visceral adiposityall of which independently contribute to lower inflammatory burden
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World J Surg Onc 22 , 345 (2024)
Semaglutide is administered as a subcutaneous injection once a week
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