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Pyroglutamic acidosis: a rare cause of metabolic acidosis in a malnourished patient

At 10 mg/mL : The top two rungs exceed a single 100-unit barrel, so at 12.5 and 15 mg the volume must be split across two injections or the vial reconstituted at a higher concentration with less water

If tolerated, the documented approach is to stay at the current step for the full interval before the next scheduled escalation not to leapfrog steps

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In this context, increased aspartate levels in the lungs contribute to the establishment of cancer cells and lung metastases