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This diagram from Qin et al
Weight loss: Often 15-25 pounds cumulative, amplifying metabolic benefits
This pattern happens because higher doses lead to greater activation of GLP1 receptors in areas of the brain that influence appetite and satiety
IGF-1 increases cardiac output, stroke volume, contractility, and ejection fraction, aiding recovery after myocardial infarction
When stratified by comparator groups, the pooled estimate was most favorable in monotherapy trials versus placebo (SMD 2.41, 95% CI 4.43 to 0.39), whereas the add-on designs versus the same background treatment (SMD 0.65, 95% CI 1.85 to 0.55), head-to-head comparisons versus another drug (SMD 0.19, 95% CI 0.84 to 0.45), and add-on designs versus placebo (SMD 0.65, 95% CI 1.35 to 0.06) showed more modest estimates and did not provide clear evidence of a between-group difference overall (p=0.21)
