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Orlistat A randomized trial ( n = 86) evaluated the efficacy of orlistat at a dose of 120 mg three times daily for three months, compared to placebo, both combined with lifestyle intervention [170]

Uemura Y et al, 2023)

Individuals with Obesity or Overweight : Semaglutide is used for weight loss in individuals with a body mass index (BMI) above 30, or above 27 if they have weight-related health issues

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These two dimensions of PAIS must be taken into account, in order to have a chance of deciphering interactions between them