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In the SURMOUNT-4 trial, participants who discontinued tirzepatide after 36 weeks experienced significant weight regain compared to those who continued treatment

2016 Jan 1;27:16-26

10.2337/diacare.19.12.1399 Diabetes Care 76 LasleyB

00:18:15 Steve Small: Yeah

Pyridoxine (B6) has been shown to augment antioxidant responses, potentially by upregulating the expression of the nuclear gene Nrf2, while also decreasing mitochondrial ROS levels [176]