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Nevertheless, these effects on gonadal structure and sperm quality were partially lost after administration of GLP-1R antagonist exendin (9-39), thus suggesting that dapagliflozin may protect against diabetes-induced spermatogenic dysfunction via GLP-1R/PI3K/Akt-dependent pathway [165]
Individuals with personal or family history of Medullary Thyroid Cancer (MTC) or MEN2 Syndrome
Growing Use Cases: Recent clinical trials have shown that GLP-1RAs can also support reducing cardiovascular risk and heart failure-related symptoms and slow down the progression of kidney diseases
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