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Preclinical studies in rodent models of cortical contusion and ischemia/reperfusion injury consistently demonstrate that riboflavin administration (typically 120 mg/kg oral or parenteral) reduces lesion volume, brain edema, astrocytosis, and apoptotic cell death, while enhancing sensorimotor recovery and spatial memory performance (56)

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By 12 weeks on the medication, that initial fatigue is generally resolved, according to the International Association for Physicians in Aesthetic Medicine

Mastaitis, Jason W., et al