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[16] [17] Discuss your injection site preferences with your diabetes specialist nurse, who can assess your subcutaneous tissue and provide personalised recommendations

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Megalin is expressed along the apical aspect of proximal tubules, where it is responsible for hepatocyte-derived AGT reabsorption and its homeostasis in kidney

10.1056/NEJMoa1504720 44 ZinmanB.BhosekarV.BuschR.HolstI.LudvikB.ThielkeD.et al (2019)

Additionally, if you notice reduced effects at a dose that previously worked well, degradation is a possible cause

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