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When evaluated with more sensitive and reliable 24-h continuous monitoring and in thorough QT studies, two of the long-acting GLP-1 RAs, liraglutide and albiglutide, were shown to cause a pronounced increase in the 24-h time-averaged mean HR from baseline of up to 610 bpm, while for dulaglutide and exenatide LAR, the increase in 24-h mean HR was 34 bpm [23, 24, 27,28,29,30]
Patients with disc-at-risk anatomy or vascular risk factors should be counseled about NAION symptoms, while current data on AMD and retinal vein occlusion do not justify altering GLP-1 therapy
Oro, MD, PhD, a professor of dermatology and associate director of the Center for Definitive and Curative Medicine at Stanford University
Ongoing monitoring helps ensure comfort and effectiveness
Patience during titration directly translates to better tolerability
Signal detection based on SOC levels The pharmacovigilance analysis revealed that adverse drug reactions (ADRs) associated with concomitant administration of GLP-1 receptor agonists and metformin spanned 27 distinct System Organ Classes (SOCs), as depicted in Fig
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