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Global, regional, and national burden of cardiovascular diseases attributable to metabolic risks across all age groups from 1990 to 2021: an analysis of the 2021 global burden of disease study data

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It may occur more quickly on re-exposure to the same drug

Under stress, there was an observed increase in biochemical markers such as H 2 O 2 , MDA, and electrolyte leakage contents, indicative of ROS occurrence

Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes