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Moreover, the phosphorylation of Y1003 provides a direct docking site for the SH2-like crystal structure of Cbl (TKB) domain of Cbl ubiquitin ligase and is required for ligand-dependent ubiquitination and Met receptor degradation

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doi: 10.1007/s10787-024-01499-8

Interestingly, direct injections of Ex-4 into the gustatory cortex of mice maintained on a high-fat diet reduced intake only when the fat density of the test diet differed from that of the maintenance diet, regardless of whether the shift was from high- to low-fat or low- to high-fat relative to the maintenance diet

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