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The transcriptional regulation of DNL is mainly orchestrated by two key transcription factors: sterol regulatory element-binding protein 1c (SREBP1c), which is activated by insulin and liver X receptor , and carbohydrate regulatory element-binding protein (ChREBP), which is activated by carbohydrates [41,42,43] (Fig

FDX1, as a key regulator of cuproptosis, efficiently reduces relatively stable Cu 2+ to the more cytotoxic Cu, ultimately inducing cuproptosis [12]

421 Specifically, dysfunction within the ventrolateral periaqueductal gray (vlPAG)-mediated descending pain modulatory system has been reported in patients with PDPN

Animal studies showed that resetting the circadian clock by time-restricted feeding improves metabolic syndrome and inhibits the development of cancer 10,11

Stebbins, G

Lushchak, 2012