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When administered as a once-weekly subcutaneous injection, Ozempic helps to: Stimulate insulin secretion from the pancreas in response to elevated blood glucose levels Suppress glucagon release , reducing the liver's production of glucose Slow gastric emptying , which helps control post-meal blood sugar spikes Reduce appetite , often leading to weight loss as a secondary benefit The mechanism of action centres on the GLP-1 receptor, which is found in various tissues including the pancreas, brain, and gastrointestinal tract
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With regard to glucose metabolism, seven studies measured levels of fasting insulin and fasting glucose and conducted the test of homeostatic model assessment of insulin resistance (HOMA-IR) (1)
Blood 94:322b, 1999
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