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A 2022 study in the Journal of Cosmetic Dermatology found that subjects who applied L-ascorbic acid followed immediately by GHK-Cu experienced 40% higher transepidermal water loss (TEWL) and delayed barrier recovery compared to those who separated application by eight hours or more
Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, et al
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Because large studies did not show robust, reproducible weightloss outcomes, development as a formal obesity drug was discontinued, and AOD9604 today is typically used offlabel as a wellness or bodycomposition adjunct rather than an FDAapproved obesity medication
Additionally, given the tremendous increase in utilization of incretin hormone medications, unforeseen adverse events may emerge that were not identified in the pivotal clinical trials, such as psychiatric events, hair loss, and ocular complications (172)
Preclinical studies have explored its involvement in repair processes, vascular adaptation, and inflammatory regulation, positioning it as a molecule of interest in musculoskeletal and gastrointestinal research contexts (1)
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