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Relevant evidence-based benefits of beta-alanine include

They counteract elevated ghrelin

O verweight individuals with a BMI 27 kg/m and at least one weight-related comorbidity (such as hypertension, hyperlipidemia, type 2 diabetes, sleep apnea, etc.)

Injectable options with established authorisation: Semaglutide 2.4 mg (Wegovy) : A once-weekly GLP-1 receptor agonist injection authorised by the MHRA for chronic weight management

Kim SH, Park MJ

Retatrutide came up on JRE #2421 with Derek (More Plates More Dates) in December 2025, which is the source of the clips circulating as "Joe Rogan on retatrutide" the discussion treated it as an investigational compound, not as something Rogan endorsed or said he uses