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Although GLP-1 signaling interacts with other metabolic systems, evidence in the supplied papers supports a primary role in reducing food intake and externally driven eating rather than a simple generalized increase in energy expenditure
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This is not an indictment
high pharmacologic doses (1-3 g/day) can cause hypotension, insulin resistance, and hepatotoxicity
Many people find their effective dose somewhere between 1.0 and 1.7 mg
C., Zelli, D., Svenningsson, P., McEwen, B
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