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Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription
If results indicate inferior PK propertiessuch as high clearance, short half-life (t 1/2 ) and/or low bioavailabilityPD effects will likely be sub-optimal
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[68]J.L
Whereas the specific mechanism underlying these observations remains unclear, there is evidence that HDL exert favorable effects on pancreatic -cell function
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