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Clinical and experimental reproductive medicine
While some epidemiological studies have raised questions about growth hormone and cancer risk, the evidence remains inconclusive after decades of clinical use
High protein intake is safe for most adults but should be discussed with a physician if you have kidney disease, as high protein diets can affect kidney function in people with pre-existing kidney impairment
The primary endpoint will be bodyweight change (week 80 and 104), change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in the OA subset, and change in Apnoea-Hypopnea Index (AHI) in the OSA subset
doi: 10.1016/S0140-6736(18)32261-X 87 GiuglianoDScappaticcioLLongoMCarusoPMaiorinoMIBellastellaGet al
Additionally, this study was performed in male mice, and studies in female mice are warranted due to potential differences in the weight loss response after semaglutide/BI8271 between sexes
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