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Clinical Significance: Interestingly, for the vast majority of patients, these antibodies did not neutralize the effect of the drug or increase the risk of side effects

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"FDA approves Novo Nordisk's oral semaglutide for cardiovascular (CV) risk reduction in adults with type 2 diabetes who are at high risk, including those who have not had a prior CV event" (Press release)

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The PCR products were then joined through overlap extension PCR (SOE PCR) at an equal mole ratio to obtain the six types of N-signal-GST-EGFP-GPI/TMDs coding regions