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SYNERGY-NASH: Tirzepatide and metabolic steatohepatitis (MASH) SYNERGY-NASH (Loomba et al., NEJM 2024, NEJMoa2401943, PMID 38856224) is a phase 2 trial in 190 patients with metabolic steatohepatitis (MASH) and biopsy-proven stage 2 or 3 fibrosis

Why Diarrhea May Worsen or Persist After 12 Months Tolerance to nausea and appetite suppression typically improves by month 6, but tolerance to digestive side effects develops unevenly

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Ginger tea, peppermint water, or small sips of electrolyte solution between meals can also ease symptoms without adding calories or challenging your digestion

How much food can I eat before I feel sick on tirzepatide