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Translating the pharmacology of dual GLP-1/GIP agonists into actionable preclinical data requires tools capable of detecting receptor engagement with cellular and spatial resolution , challenging because GLP-1R and GIPR are low-abundance membrane proteins, and no reliable commercial antibody exists for GIPR detection in primary tissues

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doi: 10.3389/fimmu.2020.531491 51 BessedeAPeyraudFLe MoulecSCousinSCabartMChomyFet al

Available at: Buonanno S, Gaggiano C, Terribili R, Cantarini L, Frediani B, Gentileschi S