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Onodera et al

Merlini, M

But if they materialize, the jump to $100bn is plausible

doi: 10.3727/096368911X576027 29 ChristoffelD

Energetically favorable literally means that it has a more negative Gibbs free energy, which typically means that the protein is more compact and makes more interactions with itself, like in the rough sketch of a protein on the right side of Figure 6

Given the market's strong returns over the past few years, it may be a good idea to be conservative and project out a much lower rate of return in the long run