High-fat foods like peanut butter may exacerbate gastrointestinal side effects (nausea, discomfort) in some patients, particularly during dose escalation
According to the Summary of Product Characteristics (SmPC), the most commonly reported adverse effects include: Nausea and vomiting (very common) particularly during dose escalation Diarrhoea or constipation (very common) affecting bowel regularity Abdominal pain and discomfort (common) often mild to moderate Reduced appetite (very common) contributing to weight loss Dyspepsia (common) indigestion or heartburn Injection site reactions (common) such as redness or irritation Fatigue (common) tiredness or lack of energy These gastrointestinal symptoms typically diminish over time as the body adjusts to the medication
Can you combine multiple fat loss peptides safely
Some people also pair semaglutide with supplements like berberine to support metabolic outcomes
Fandio, J., Toba, L., Gonzlez-Matas, L
Bioinformatics 26 , 29692976 (2010)