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When the body is overwhelmed or unbalanced, this translates to its largest organ, which is the skin
Moreover, hyperglycemia impairs the expression of Sox9, a key factor of Paneth cell differentiation involved in stem cell maintenance and the expression of stem cell markers Lgr5 and Musashi RNA-binding protein 1 (Msi1) and transit-amplifying cells marker prominin 1 (Prom1)
P7 was known with longstanding bowel problems with significant bloating, nausea, vomiting, and constipation and was found to have a slow gut motility
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