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This evidence suggests that using these treatments together, leveraging their complementary actions, could enhance their effectiveness [101]
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PCOS is a heterogeneous condition with distinct endocrine, inflammatory, and metabolic phenotypes
8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs
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