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PI3K/Akt/mTOR Signaling Cascade A primary downstream pathway of IGF-1R activation is the PI3K/Akt/mTOR cascade, which regulates cell survival, protein synthesis, and metabolic homeostasis

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In most other countries the maximum time between injections is two months

In Schwann cells, Rheb gene knockdown was utilized to specifically inhibit PDH activity, which shifted the metabolic pattern towards a lactate-predominant oxidized route, thereby transporting increased lactate into peripheral axons

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