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they also each tickle those receptors in a unique way
Gastrointestinal effects dominate: nausea (1722%), diarrhea (1316%), vomiting (610%), decreased appetite (79%), and indigestion (~7%)
Rats treated with colonic acetic acid infusions exhibited low plasma GLP-1 levels and high serotonin levels in plasma and colonic tissues
Increased susceptibility of polyunsaturated fatty acids to peroxidation generates reactive lipid species that disrupt membrane integrity and compromise mitochondrial function
Over time, this can reduce thyroid hormone production, leading to hypothyroidism and symptoms such as weight gain, fatigue, sensitivity to cold and a slower metabolism