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Current Rheumatology Reports , 26 (12), 403413
Supporting insulin release to manage blood sugar levels
& Weiss, J
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SAR441255 demonstrated superior weight loss compared to dual GLP-1/GCG agonists in animal models and did not exhibit major cardiovascular adverse effects in lean monkeys
Engaging all three pathways simultaneously drives glucose-dependent insulin secretion through the two incretin arms while adding glucagon-receptor agonism implicated in energy expenditure, the pharmacological rationale that distinguishes it from single (GLP-1 (Sema)) and dual (GLP-2 (Triz)) incretin agonists
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