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While the researchers in this study utilized pre-existing data available to them and did not directly measure alcohol or opioid use, they found clinically meaningful associations between semaglutide/tirzepatide-type weight loss medication prescription and reductions in alcohol intoxication and opioid poisoning events in patients at risk for these deleterious health outcomes
The article notes that impairment can affect how both agents are handled and increases accumulation risk, and that the NAD salvage pathway involves liver enzymes
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They integrate clinical oversight and habit-change coaching rather than being delivered as siloed, disconnected services
Direct neurotoxicity (unlikely but not ruled out)
The results of three-chamber testing revealed significant social behavioral deficits in the MIA mice compared to controls
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