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Name: tirzepatide and hfpef Bridging the gap between GLP1-receptor agonists cardiovascular outcomes: evidence for the role of | Cardiovascular Diabetology Semaglutide and Tirzepatide vs Sitagliptin
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A decrease in the antioxidant capacity of the brain may have functional consequences through cell damage, chronic inflammation, protein, and DNA damage

Thus, it seems that DSIP may indeed play a role in altering physiology in preparation of the body for sleep, as some of it effects occur before neurological and behavioral signs of sleep