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GLP-1 RAs may thus offer benefit in select cases, particularly where some hypothalamic function is preserved
Knockout animals show hyperinsulinemia and insulin resistance, hyperglycaemia and osteoarthritis (281), hepatic steatosis and therefore obesity
If that happens, it may be worth considering some of the other medications approved for weight loss that are not GLP-1s
They are pathway-level markers that do not predict response
17,18 In the authors experience, it is often possible to eliminate the sulfonylurea altogether, which can be advantageous in terms of avoiding hypoglycemia, minimizing the complexity of the diabetes regimen, and augmenting the weight loss benefits of the GLP-1 RA
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