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We monitored the real-time cell surface dissociation of exendin-4-FITC, exendin-phe1-FITC, and exendin-asp3-FITC in the presence of exendin(9-39), having first inhibited endocytosis using a cocktail of metabolic inhibitors 9 (Fig
Pharmacol Rep 2016;68:32937.ArticlePubMed 40
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2.2 Culture and treatment of human umbilical vein endothelial cells (HUVECs) HUVECs were purchased from Shanghai Zhong Qiao Xin Zhou Biotechnology Co., Ltd
In a remarkably streamlined regulatory mechanism, it orchestrates systemic iron flux by binding to the only known mammalian cellular iron exporter (ferroportin) on the surface of iron-releasing cells (macrophages and enterocytes), blocking cellular iron release into the circulation
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