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Retrieved from Karamanolis, G., Theofanidou, I., Yiasemidou, M., Giannoulis, E., Triantafyllou, K., & Ladas, S
J Biol Chem (1984) 259(22):140827
This conservative approach allows for assessment of individual tolerance before increasing to the 2-5mg range used in more intensive protocols
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Tretinoin, aka retinoic acid, is the active ingredient our skin cells can understand and retinyl palmitate (RP) has to be converted by our metabolic machinery to actually do something
Others experience it as a loss of pleasure or mild emotional flatness around food. Trial mood scores moved slightly better rather than worse, so the negative experience appears to be a minority signal that standard adverse-event tables do not capture well
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