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Trial Structure Duration: 48 weeks of treatment Participants: 338 adults randomized 2:1:1:1:1:2:2 to placebo or retatrutide groups Doses tested: 1mg, 4mg, 8mg, 12mg (all with slow titration from 2mg starting dose) Lifestyle intervention: All participants received counseling on diet (500 kcal/day deficit) and exercise (150 min/week) Primary endpoint: Percent weight change at 24 weeks Key secondary endpoints: Weight change at 48 weeks, proportion achieving 5%, 10%, 15% loss The trial used a slow titration protocol to minimize side effects: all groups except the 1mg dose started at 2mg weekly and escalated every 4 weeks

Best For Patients who want a proven, well-studied option with the longest clinical experience Patients who have plateaued on other weight loss strategies and need pharmaceutical support for the first time Patients with milder obesity or 30 to 50 pounds to lose Patients who prioritize cost-effectiveness Patients with type 2 diabetes seeking combined glycemic and weight benefits Read more on the semaglutide service page or our article on what happens when you stop semaglutide

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These prescription medicines mimic glucagon-like peptide-1, a natural human hormone that regulates blood glucose and appetite