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While these trials excluded patients with a formal diagnosis of type 2 diabetes, its highly plausible that a substantial proportion of participants had early metabolic abnormalities, such as insulin resistance , elevated fasting insulin , or even undiagnosed prediabetes

A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance

Analyst 139, 54395450

Vitamin C (ascorbic acid), a water-soluble compound, directly scavenges hydroxyl and superoxide radicals, and has been shown to inhibit the expression of Atrogin-1 and MuRF1, thereby reducing ROS-induced proteolysis and delaying muscle wasting in animal models (Takisawa et al., 2019)

Eur J Nutr 2015 Mar;54(2):251-263