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In times of reduced glucose (i.e., fasting, extended exercise, ketogenic diet), the body diverts the acetyl-CoA produced from the fatty acids into ketogenesis
A Phase 2 substudy showed 26.1% fat mass reduction with limited lean mass loss
Keys to the switch of fat burning: stimuli that trigger the uncoupling protein 1 (UCP1) activation in adipose tissue
Fucoxanthin: A carotenoid found in certain seaweed, shown to influence fat metabolism (4)
Among late phase trials, Lixisenatide (n = 5) showed the lowest eligibility rates (5.8% Non-Asian US) due to strict HbA1c requirements (7.510%), while Dulaglutide (n = 7) showed the highest variability (SD = 46.2%)
doi: 10.1093/ajcn/nqaa264 8
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