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In the phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), participants receiving higher doses of retatrutide achieved mean weight reductions of up to 17.5% of body weight over 24 weeks, with greater losses reported at 48 weeks

The medication slows gastric emptying, which contributes to prolonged feelings of fullness after meals

When paired with smart eating habits, particularly protein-focused meals, it supports fat loss while preserving lean muscle mass

Supplies and Practical Considerations Unused liraglutide pens can be stored refrigerated (2 to 8C) until the expiration date

Dosing and How to Take Them Semaglutide Dosing For weight loss (Wegovy): Start: 0.25 mg weekly for 4 weeks Increase gradually to 2.4 mg weekly Take as injection under the skin once per week Also available as daily pill (Rybelsus) for diabetes Tirzepatide Dosing For weight loss (Zepbound): Start: 2.5 mg weekly for 4 weeks Can increase up to 15 mg weekly Take as injection under the skin once per week Only available as injection, not as pills Both medications work best when you increase the dose slowly

Gut microbiome : When beneficial gut bacteria ferment fiber, they produce short-chain fatty acids (SCFAs)