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Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above
This point deserves emphasis
Autophagy (2014) 10(2):3823
Safety: No toxic dose has been determined to date Study in rats with a single 20mg/kg IM dose, no deaths, abnormalities in body weight, food intake, or behavior noted Study in dogs at 10mg/kg IM showed no adverse effects Study in rats of 28 days of 0.2 mg, 1mg, or 4mg/day IM no changes relative to saline injection Study in dogs of 0.1 mg, 0.5 mg, or 2 mg/day IM no changes relative to saline injection Uses: Study: protection against NSAID and alcohol adverse effects Study: healing actions on wound and injuries from trauma and systemic issues Study: benefits in neuropsychiatric conditions like depression, though other studies show it has poor penetration of the blood brain barrier
1996 Nov 1;12(16):1537-41
Insufficient Evidence for: The following purported benefits are only supported by limited, low-quality clinical studies
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