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Reported side effects in humans Clinical experience and user reports suggest that side effects, when they occur, are generally mild
They just may not be enough on their own once NAD+ depletion has already begun
Efficacy of Different Routes of Vitamin B12 Supplementation for the Treatment of Patients with Vitamin B12 Deficiency: A Systematic Review and Network Meta-Analysis. Irish Journal of Medical Science, 17 Jan
At the same time, more of your existing NAD+ gets consumed by enzymes like CD38 and PARPs, which are activated by things like inflammation, oxidative stress, and DNA damage
But that isnt new
Elevated NNMT expression has been observed in adipose tissue of animals with insulin resistance, and modulation of this enzyme has been shown to influence weight and metabolic function in preclinical models
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