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Butyrate is the primary energy source for colonocytes, as it strengthens tight junction proteins (zona occludens-1 (ZO-1) and claudins), reducing intestinal permeability

Fehm et al

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[44] [46] Finally, glutaryl-CoA is oxidatively decarboxylated to crotonyl-CoA by glutaryl-CoA dehydrogenase (E.C 1.3.8.6), which goes on to be further processed through multiple enzymatic steps to yield acetyl-CoA